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Annual Resident & Fellow Research Presentation Day 2011 Program

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9:00 AM Introduction and Welcome
9:10 AM 1. Combating resident fatigue: A novel approach to quantifying the incidence, risk and specific time-intervals of fatigue-related impairment
Frank McCormick, M.D., John Kadzielski, M.D., Christopher P. Landrigan, M.D. MPH, Brady Evans, BS, James Herndon, M.D., M.B.A., Harry Rubash, M.D.
Harvard Combined Orthopedic Surgery Program, Massachusetts General Hospital, Boston, MA
9:20 AM 2. Impact of Lap-Band Size on Weight Loss: Does Gender Matter?
Ali Ardestani, M.D., Malcolm K. Robinson, M.D., David B. Lautz, M.D., Ashley H. Vernon, M.D., Ali Tavakkolizadeh, M.D.
Brigham and Women's Hospital, Boston, MA
9:30 AM 3. EphB4 activates endothelial nitric oxide synthase to limit vein graft thickening
Michael Collins MD, Akihito Muto MD, PHD, Amanda Feigel MD, Matthew Goodwin BS, Kenneth Ziegler MD, Clinton Protack MD, Lynn Model MD, Alan Dardik MD, PHD
Yale University, Department of Surgery, New Haven, CT
9:40 AM 4. The Antiproliferative Effects of Pterostilbene on Breast Cancer In Vitro are via Inhibition of Constitutive and Leptin-Induced JAK/STAT3 Activation
Denise McCormack, MD, John Schneider, MD, Debbie McDonald, BS, David McFadden, MD
University of Vermont, Surgery Research, Burlington, VT
9:50 AM 5. Activatable Collagenase Activity in a Rat Model of Bile Duct Ligation
Sean Ciullo, M.D., Christopher Muratore, Yonghong Zhou, Thomas F. Tracy Jr.
Rhode Island Hospital, Department of General Surgery, Providence, RI
10:00 AM 6. Roscovitine enhances the cytotoxicity of hyperthermia and hyperthermic chemotherapy in colon cancer cells
Matthew J Furman, MD, Barur R Rajeshkumar, PhD, Giles F Whalen, MD, and Laura A Lambert, MD
University of Massachusetts Medical School, Department of Surgery, Worcester, MA
10:10 – 10:30 AM Break
10:30 AM 7. A Novel Vascular Role for PirB in Ischemia-Induced Postnatal Angiogenesis
Caroline C. Jadlowiec, MD, Robert A. Brenes, MD, Clinton D. Protack, MD, Susun T. Kim, BA, Xin Li, MD, Alan Dardik, MD, PhD
Yale University, Department of Vascular Surgery, New Haven, CT
10:40 AM 8. The Neurokinin-1 Receptor: A Gateway to Postoperative Adhesion Formation and Prevention
Michael R. Cassidy, MD, Holly K. Sheldon, MD, Melanie L. Gainsbury, MD, Hisashi Kosaka, MD, PhD, Arthur F. Stucchi, PhD, James M. Becker, MD, FACS
Boston University Medical Center, Department of Surgery, Boston, MA
10:50 AM 9. The Efficacy and Safety of Sunitinib in the Prevention of Pelvic Adhesion Formation in a Rabbit Model
Erica M. Fallon, MD1, Deepika Nehra, MD1,2, Alexis K. Potemkin, RN, BSN1, Hau D. Le, MD1, David W. Brown, MD3, Arthur P. Nedder, DVM4, Mark Puder, MD, PhD1
1Department of Surgery and The Vascular Biology Program, Children’s Hospital Boston, Boston, MA 2Department of Surgery, Massachusetts General Hospital, Boston, MA 3Department of Cardiology, Children’s Hospital Boston, Boston, MA 4Animal Resources, Children’s Hospital Boston, Boston, MA
11:00 AM 10. Cancer stem/progenitor cells respond poorly to chemotherapeutic agents
Katia Meirelles1, Leo Andrew Benedict12, Fengshen Chen1, David Dombkowski1, Kai Lu, Frederic I. Preffer1, Jose Teixeira1, David T. MacLaughlin1, Patricia K. Donahoe1, and Xiaolong Wei1
1Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, MA 2Department of Surgery, Tufts Medical Center, Boston, MA
11:10 AM 11. An Examination of the Effect of Patient-Centered Websites on the Surgeon-Patient Relationship Using the Rare Cancer Syndrome, Pseudomyxoma Peritonei
Shawn Fu, MD, Edward Feller, MD, Thomas Miner, MD
Brown Medical School/Rhode Island Hospital, Department of Surgery, Providence, RI
11:20 AM 12. Hypoglycemia is an Independent Risk Factor for the Development of Hospital-Acquired Infections in the Surgical Intensive Care Unit
Holly K. Sheldon, MD, Joanna Ng, MD, Gustavo Bauza, MD, Juan Rodolfo Mella, MD, Melanie Gainsburgy, MD, Peter Burke, MD, Suresh Agarwal, MD
Boston University School of Medicine, Department of Surgical Research, Boston, MA
11:30 AM 13. Influence of patient demeanor on clinical performance and medical education: results from a clinical simulation pilot study
Andrew J. Eyre, Ted A. James, MD, Cate Nicholas, MS, PA, EdD
University of Vermont College of Medicine, Surgery/Medical Education, Burlington, VT
11:40 AM 14. PARP-1 Deficiency Augments Intimal Hyperplasia in a Mouse Model of Arterial Injury
Chandler A. Long, Hassan Albadawi, Shirling Tsai, Hyung-Jin Yoo, Rahmi Oklu, Mitchell H. Goldman and Michael T. Watkins
Massachusetts General Hospital, Department of Endovascular and Vascular Surgery, Boston, MA
11:50 – 12:50 PM Lunch
12:50 PM 15. Surgical Method for Delivering hMSCs utilizing Biopolymer Microthreads in SCID Mice
Diego S. Illanes1, Allison E. Howard1, Nicole A. Otto2, Jonathan M. Grasman2, Stephen B. Young1, Tiffany A. Moore Simas1, Glenn R. Gaudette2, Dale L. Greiner3 and George D. Pins2
1Department of Obstetrics and Gynecology, UMass Memorial Health Care and University of Massachusetts Medical School, Worcester, MA 2Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 3Department of Medicine, University of Massachusetts Medical School, Worcester, MA
1:00 PM  16. Omega-3 Fatty Acids Inhibit the Growth of Neuroblastoma Tumors and Induce A Tumor Specific Essential Fatty Acid Deficiency in a Murine Xenograft Tumor Model
Deepika Nehra MD, Hau D. Le MD, Erica M. Fallon MD, Vincent E. de Meijer MD MSc, Amy H. Pan BA, Paul D. Mitchell MS and Mark Puder MD PhD
Chidren's Hospital Boston, Department of Surgery & The Vascular Biology Program, Boston, MA
1:10 PM  17. A novel in vitro flow model that recapitulates alterations of vessel identity during vein graft adaptation in vivo
Yale University School of Medicine, Department of Surgery, New Haven, CT
1:20 PM 18. Anti-inflammatory effect of intestinal alkaline phosphatase on the nucleotide uridine diphosphate
Angela K Moss MD, Madhu Malo MD PhD, Halim Yammine MD, Sundaram Ramasamy PhD, Kanakaraju Kaliannan MD, Sayeda Alam MD, Nur Muhammad MD, H. Shaw Warren MD, Elizabeth Hohmann MD, Richard A Hodin MD
Massachusetts General Hospital, Department of Surgery, Boston, MA
1:30 – 2:30 PM “Quality Assessment in Surgery: World Gone Wrong”
Keynote Speaker: Neil Hyman, MD
A. Galitsky1, L. Sillin1, D. M. Brams1, S. Wong2, D. Nepomnayshy1
1Lahey Clinic, Department of General Surgery, Burlington, MA 2Tufts Medical School, Boston, MA
2:40 PM  20. Higher Flow Rates Improve Heating During Hyperthermic Intraperitoneal Chemoperfusion
Matthew J Furman MD, Mark J Wante CCP, Robert J Picotte CCP, Barur R Rajeshkumar PhD, Giles F Whalen MD, and Laura A Lambert MD
University of Massachusetts Medical School, Department of Surgery, Worcester, MA
2:50 PM  21. Analysis of adverse events in pediatric surgery using criteria validated from the adult population; justifying the need for pediatric-focused outcome measures
Samuel Rice-Townsend, MD; Matthew Hall, PhD; Kathy J. Jenkins, MD, MPH; David W. Roberson, MD, MPH; Shawn J. Rangel, MD, MSCE
Children's Hospital Boston, Department of Surgery, Boston, MA
3:00 PM 22. Early Fasciotomy in Patients with Extremity Vascular Injury is Associated with Decreased Risk of Adverse Limb Outcomes: A Review of the National Trauma Data Bank
Tze-Woei Tan, Jeffrey A. Kalish, Fernando Joglar, Naomi M. Hamburg, Timna Onigman, Denis Rybin, Gheorghe Doros, Robert T. Eberhardt, Alik Farber
Boston Medical Center, Vascular and Endovascular Surgery, Boston, MA
3:10 PM  23. Massive Transfusion Protocol at a Level I Trauma Center: A Quality Improvement Project
Darrell Doucette, MD, Timothy A. Emhoff, MD
University of Massachusetts Medical School, Department of Surgery, Worcester, MA
3:25 PM Awards

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