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Hepatic Multiprobe Radiofrequency Ablation in the Porcine Model

David A Iannitti, Sr., Jason McKee, Carolyn Simon, Damian Dupuy
Brown Medical School, Providence, RI

Evaluate a multiprobe radiofrequency ablation (RF) device in an in-vivo liver model.
Nonrandomized trial.
Tertiary care hospital animal facility.
Eight pigs
Two monopolar 3.0 cm LeVeen radiofrequency probes spaced at 3.5 cm. were deployed into the liver. Ablation performed with a 200 watt RF generator according to impedance based algorithms, half with Pringle maneuver. Liver removed for gross and histological assessment.
Main Outcome Measurements:
Ablation dimensions, time, and histology.
Twelve ablations were performed resulting in a mean length of 7.0 cm and width of 2.9 cm (95% CI, 6.9 to 7.1; 1.8 to 4.0) in an average time of 596 sec. Pringle vs. No Pringle resulted in ablation times of 359 vs. 834 sec (P<0.05); ablation length 6.9 vs. 7.0 cm.; ablation widthlat 3.4 vs. 2.9 cm.; and ablation widthcentral 3.1 vs. 2.1 cm. Ablation volumes for the Pringle vs. No Pringle groups were 54.0 +/- 11.7 cm3 vs. 34.9 +/- 4.8 cm3 (P<0.05).
Multiprobe RFA is a developing technology that has not yet been tested in perfused liver. The two probes have a synergistic effect which creates a larger area of ablation than two individual burns. The volume of thermocoagulation was significantly larger and the central area of ablation was more consistent in the Pringle group with a significantly shorter ablation time. This technology is promising but will need more evaluation to determine its clinical utility.

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